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Approved to treat depression in 1985, these days Wellbutrin (bupropion hydrochloride) generally means the new once-a-day form, Wellbutrin XL, or the somewhat older sustained released (SR) version, now available as a generic.

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Antidepressants affect levels of neurotransmitters that govern mood, and Wellbutrin in particular is thought to elevate mood by lowering levels of the neurotransmitter dopamine.

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